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Related Concept Videos

Clinical Trials01:16

Clinical Trials

6.7K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Ethics in Research01:56

Ethics in Research

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Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Longitudinal Research02:20

Longitudinal Research

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.9K
Hazard Ratio01:12

Hazard Ratio

110
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
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Case Studies01:22

Case Studies

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There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
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Related Experiment Video

Updated: Jun 21, 2025

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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A crisis in clinical research.

David S Hong1, Patricia LoRusso2, Mario Sznol2

  • 1Division of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA dshong@mdanderson.org.

Journal for Immunotherapy of Cancer
|July 11, 2024
PubMed
Summary

Clinical research for cancer treatments faces significant delays post-COVID-19 due to systemic issues. The Society for Immunotherapy of Cancer (SITC) summit identified problems and solutions to revitalize cancer drug development.

Keywords:
clinical trials as topicclinical trials, phase II as topicclinical trials, phase III as topicimmunotherapy

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Area of Science:

  • Oncology
  • Clinical Trials
  • Immunotherapy

Background:

  • The clinical research pipeline is essential for developing new cancer treatments.
  • Progress has been hindered by systemic inefficiencies, exacerbated by the COVID-19 pandemic.

Purpose of the Study:

  • To highlight the current crisis in clinical research.
  • To stimulate discussion on solutions for reinvigorating the field.

Main Methods:

  • The Society for Immunotherapy of Cancer (SITC) hosted a virtual summit.
  • The summit characterized key issues and potential solutions within clinical research.

Main Results:

  • Systemic inefficiencies have slowed clinical research progress.
  • The summit identified critical areas needing improvement.

Conclusions:

  • Urgent action is needed to address the clinical research crisis.
  • Reinvigorating clinical research is crucial for future patient care and novel cancer therapies.