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Updated: Jun 21, 2025

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Aging and cognitive resilience: Molecular mechanisms as new potential therapeutic targets

Ana Cordeiro1, Catarina Gomes2, Joana Bicker2

  • 1Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.

Drug Discovery Today
|July 11, 2024
PubMed

Insights

As people age, understanding cognitive resilience is key to developing new therapies for age-related cognitive decline. This review explores molecular factors and therapeutic strategies to enhance brain health and extend healthspan.

Area of Science:

  • Neuroscience
  • Gerontology
  • Molecular Biology

Background:

  • Global population aging necessitates strategies to prolong lifespan and healthspan.
  • Cognitive resilience is crucial for maintaining quality of life during aging.
  • Understanding age-related cognitive decline and its molecular underpinnings is vital.

Purpose of the Study:

  • To critically review molecular mechanisms of cognitive resilience.
  • To analyze emerging therapeutic strategies for age-related cognitive decline.
  • To synthesize insights from animal and human studies.

Main Methods:

  • Literature review and critical appraisal.
  • Analysis of molecular determinants of cognitive resilience.
  • Examination of genetic and epigenetic factors.

Main Results:

  • Identified key molecular pathways influencing cognitive resilience.
  • Evaluated therapeutic strategies including drug repositioning, macromolecules, and cellular therapies.
  • Synthesized findings from diverse animal and human research.

Conclusions:

  • Novel therapeutic avenues can be developed by understanding cognitive resilience.
  • Targeting molecular mechanisms offers potential to mitigate age-related cognitive decline.
  • A combination of pharmaceutical and cellular therapies may be beneficial.
Keywords:
AgingCognitive impairmentCognitive reserveCognitive resilienceNeurodegenerative diseaseNeuroinflammationNeuroplasticity

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