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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
574
Association between primary biliary cholangitis with diabetes and cardiovascular diseases: A bidirectional
Yun-Lu Lin1, Tao Yao1, Ying-Wei Wang1
1The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, PR China.
Clinics and Research in Hepatology and Gastroenterology
|July 11, 2024
Summary
Primary biliary cholangitis (PBC) causally increases the risk for type 1 and type 2 diabetes and several cardiovascular diseases (CVDs), including heart failure and myocardial infarction. No causal link was found with coronary atherosclerosis.
Area of Science:
- Genetics
- Immunology
- Cardiology
- Endocrinology
Background:
- Primary biliary cholangitis (PBC) is an autoimmune disease impacting multiple organ systems.
- Understanding the systemic effects of PBC is crucial for patient management.
Purpose of the Study:
- To investigate the potential causal relationship between genetically predicted PBC and various forms of diabetes and cardiovascular diseases (CVDs).
Main Methods:
- Utilized 2-sample Mendelian randomization (MR) analyses, including single-variable (SVMR) and multivariable (MVMR) approaches.
- Employed genome-wide association studies (GWAS) summary data for PBC and a large consortium for diabetes and 20 CVDs.
Main Results:
- Genetically predicted PBC showed a causal association with increased risk for type 1 diabetes (T1D), type 2 diabetes (T2D), myocardial infarction (MI), heart failure (HF), hypertension, atrial fibrillation (AF), stroke, ischemic stroke, and small-vessel ischemic stroke.
- MVMR confirmed independent effects of PBC on T1D, HF, MI, and small-vessel ischemic stroke.
- No evidence of a causal link between PBC and coronary atherosclerosis was observed.
Conclusions:
- This study provides evidence for causal effects of PBC on diabetes and seven specific CVDs.
- The findings highlight potential shared pathways and the systemic impact of PBC beyond the liver.
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