The burden of non-alcoholic fatty liver disease among working-age people in the Western Pacific Region, 1990-2019: an age-period-cohort analysis of the Global Burden of Disease study
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View abstract on PubMed
Summary
This summary is machine-generated.Non-alcoholic fatty liver disease (NAFLD) prevalence is rising globally, especially in working-age adults. Future projections show an increasing burden, highlighting the urgent need for NAFLD prevention strategies.
Area Of Science
- Hepatology
- Public Health
- Epidemiology
Background
- Non-alcoholic fatty liver disease (NAFLD) is a growing public health concern, particularly among working-age populations (15-64 years).
- Early diagnosis of NAFLD increases the risk of long-term disability-adjusted life years (DALYs) due to potential progression to cirrhosis or hepatocellular carcinoma.
- Understanding NAFLD prevalence trends and associated factors is crucial for effective public health interventions.
Purpose Of The Study
- To analyze global, regional, and national NAFLD prevalence trends over three decades (1990-2019).
- To investigate the associations of NAFLD prevalence with age, period, and birth cohorts.
- To provide future projections of the NAFLD burden, particularly in the Western Pacific region.
Main Methods
- Utilized Global Burden of Disease Study 2019 estimates for NAFLD prevalence in the working-age population.
- Employed age-period-cohort models to analyze trends and estimate prevalence within age groups from 1990 to 2019.
- Extracted data on age-standardized prevalence (ASPR) and calculated regional and national trends.
Main Results
- Global age-standardized prevalence of NAFLD significantly increased from 1990 to 2019.
- The Western Pacific region showed a substantial increase in NAFLD cases and prevalence over three decades.
- Age-period-cohort analysis revealed distinct patterns in the Western Pacific compared to global trends, with declining risk after age 60-64 in the region.
Conclusions
- NAFLD poses a significant and growing health burden globally and in the Asia Pacific region.
- Working-age adults are identified as a key at-risk group, with socioeconomic factors playing a role in the Western Pacific.
- Urgent NAFLD prevention strategies are necessary, supported by upward future projections of the disease burden.
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