A New Ferroptosis-Related Long Non-Coding RNA Risk Model Predicts the Prognosis of Patients With Papillary Thyroid Cancer
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.This study developed a five-ferroptosis-related long non-coding RNA (lncRNA) risk model for predicting papillary thyroid cancer (PTC) prognosis. The model accurately distinguished high-risk from low-risk patients, with specific lncRNAs showing tumor-suppressive or oncogenic roles.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Ferroptosis, a novel regulated cell death, is implicated in cancer progression.
- The role of ferroptosis-related long non-coding RNAs (lncRNAs) in papillary thyroid cancer (PTC) remains unclear.
- This study aimed to clarify the prognostic value of ferroptosis-related lncRNAs in PTC.
Purpose Of The Study
- To establish and validate a prognostic model based on ferroptosis-related lncRNAs for papillary thyroid cancer (PTC).
- To investigate the differential expression and functional roles of key lncRNAs in PTC.
- To explore the relationship between the ferroptosis-related lncRNA risk model and clinicopathological features, immune microenvironment, and m6A modification.
Main Methods
- Transcriptome data from The Cancer Genome Atlas (TCGA) were analyzed.
- A five-ferroptosis-related lncRNA risk model was constructed using multivariate Cox regression.
- Kaplan-Meier survival analysis, ROC curves, and nomograms were used for validation.
- *In vitro* assays assessed the functional roles of LINC00900, LINC01614, and PARAL1 in cell proliferation, migration, and invasion.
Main Results
- A five-ferroptosis-related lncRNA risk model (PARAL1, LINC00900, DPH6-DT, LINC01614, LPP-AS2) was successfully constructed.
- The risk score derived from the model was a more accurate predictor of PTC prognosis than traditional clinicopathological features.
- LINC00900 exhibited tumor-suppressive functions, while LINC01614 and PARAL1 acted as oncogenic lncRNAs, all influencing ferroptosis.
Conclusions
- A novel five-ferroptosis-related lncRNA risk model can effectively predict prognosis in papillary thyroid cancer (PTC).
- The study identified LINC00900 as a tumor suppressor and LINC01614 and PARAL1 as oncogenes in PTC.
- These findings provide valuable insights into the molecular mechanisms of ferroptosis in PTC and potential therapeutic targets.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...