Related Experiment Video
Updated: Jun 21, 2025
06:24
Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
276
Increased Vitamin C Intake Is Associated With Decreased Pancreatic Cancer Risk
Maria Pereira1, Matthew Cardeiro1, Lexi Frankel1
1Nova Southeastern University, Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, USA.
World Journal of Oncology
|July 12, 2024
Summary
Vitamin C intake was associated with a lower incidence of pancreatic cancer in a large national study. This suggests a potential preventative role for vitamin C in pancreatic cancer risk.
Area of Science:
- Oncology
- Nutritional Science
- Epidemiology
Background:
- Pancreatic cancer has a poor prognosis, with a 5-year survival rate around 3%.
- Diagnosis often occurs at advanced stages, contributing to low survival rates.
- Previous research suggests vitamin C may play a role in pancreatic cancer prevention and treatment.
Purpose of the Study:
- To investigate the association between vitamin C intake and the risk of developing pancreatic cancer.
- To analyze pancreatic cancer incidence in patients with and without a history of vitamin C intake.
Main Methods:
- Utilized a HIPAA-compliant national database from January 2010 to December 2020.
- Employed International Classification of Diseases (ICD-9 and ICD-10) codes for patient identification.
- Matched patients by Charlson Comorbidity Index (CCI) score and age, using chi-squared and logistic regression analyses.
Main Results:
- A total of 83,941 patients with prescribed vitamin C were identified.
- After matching, 50,384 patients were in each group (vitamin C vs. control).
- Pancreatic cancer incidence was 0.48% in the vitamin C group versus 0.88% in the control group (Odds Ratio: 0.548, P < 3.174 × 10-14).
- Vitamin C prescription was linked to lower pancreatic cancer prevalence across all ages and US regions.
- Healthcare costs were higher in the control group.
Conclusions:
- A statistically significant correlation exists between vitamin C intake and reduced pancreatic cancer incidence.
- Further research is recommended to explore vitamin C's mechanisms (redox, cofactor activity) in pancreatic cancer.
- Consideration of lifestyle risk factors like smoking alongside vitamin C is advised.
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