Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Imaging Studies III: Computed Tomography

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-term Outcomes of Partial Cystectomy for Urothelial Carcinoma in the Era of Bladder Preservation.

Urology·2026

Same author

An Analysis of Patient Recovery and Opinions on Driving Post-Transcatheter Aortic Valve Insertion (TAVI): the TAVI-D Study.

CJC open·2026

Same author

An open-source application for self-service, Health Insurance and Portability Accountability Act-compliant geocoding.

Journal of clinical and translational science·2026

Same author

Aortoenteric Fistula Thirty-Seven Years After Repair for Midaortic Syndrome.

CJC pediatric and congenital heart disease·2026

Same author

Spotting viral invaders in koala family trees.

Nature·2026

Same author

Challenging Assumptions: Association Between Clinical Hours, Simulation, and Work Experience and New Graduate Nurse Practice Readiness.

Nurse educator·2026

Search research articles

Related Experiment Video

Updated: May 7, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Predictive Value of Computed Tomography Following Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer.

Syed M Alam¹, Austin Martin¹, Matthew T McLeay¹

¹Department of Urology, University of Kansas Health System, Kansas City, KS, USA.

Bladder Cancer (Amsterdam, Netherlands)

|July 12, 2024

Summary

This summary is machine-generated.

Computed tomography (CT) scans after neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer (MIBC) poorly predict treatment response. Radiologic findings do not reliably assess disease burden before radical cystectomy (RC).

Keywords:

Urinary bladder neoplasms cystectomy diagnostic imaging neoadjuvant therapy neoplasm staging

More Related Videos

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Related Experiment Videos

Last Updated: May 7, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model

Published on: May 29, 2015

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Area of Science:

Urology
Oncology
Radiology

Background:

Neoadjuvant chemotherapy (NAC) is standard for muscle-invasive bladder cancer (MIBC) before radical cystectomy (RC).
Computed tomography (CT) is frequently used, but its accuracy in predicting treatment response after NAC is unclear.

Purpose of the Study:

To evaluate the predictive value of CT scans in assessing disease burden after NAC for MIBC.
To determine the correlation between radiologic and pathologic responses to NAC.

Main Methods:

Retrospective review of pre- and post-NAC CT scans in 141 MIBC patients.
Correlation analysis of radiologic complete response (RCR) and partial response (RPR) with pathologic complete response (PCR) and partial response (PPR).
Logistic regression to assess CT's predictive value for disease burden.

Main Results:

Pathologic complete response (PCR) was 34%; partial response (PPR) was 16%.
Positive predictive value of CT for PCR was 53.5%; for PPR, 28.8%.
No significant association found between radiologic and pathologic responses, lymph node involvement, or extravesical disease.

Conclusions:

CT findings after NAC show poor correlation with final pathology in MIBC patients.
CT should not be relied upon for evaluating local disease burden post-NAC before RC.