Related Experiment Video
Updated: Jun 21, 2025
07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
8.1K
Adrenergic Urticaria: An Updated Review
Kristin N Slater1, Ahmad Abu-Zahra2, Francisca Kartono3
1Dermatology, Lincoln Memorial University DeBusk College of Osteopathic Medicine, Harrogate, USA.
Cureus
|July 12, 2024
Summary
Adrenergic urticaria is a rare condition that can be difficult to diagnose and treat. This review consolidates current literature to help clinicians consider this subtype in differential diagnoses and explore future research and treatment avenues.
Area of Science:
- Dermatology
- Immunology
Background:
- Urticarial eruptions present diagnostic and therapeutic challenges, particularly in chronic cases.
- While several urticarial forms are established, adrenergic urticaria is less commonly reported.
Purpose of the Study:
- To consolidate existing literature on adrenergic urticaria.
- To increase awareness of adrenergic urticaria in differential diagnoses for urticarial conditions.
- To identify research gaps and suggest future treatment directions.
Main Methods:
- Comprehensive literature review.
- Synthesis of existing case reports and studies on adrenergic urticaria.
Main Results:
- Adrenergic urticaria is an under-recognized subtype of urticaria.
- Limited research exists on its specific pathophysiology and treatment efficacy.
Conclusions:
- Adrenergic urticaria warrants greater consideration in the differential diagnosis of chronic urticaria.
- Further research is needed to elucidate its mechanisms and develop targeted therapies.
Related Concept Videos
01:31Adrenergic Receptors: ɑ Subtype
1.5K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
1.5K
01:27Adrenergic Receptors (Adrenoceptors): Classification
2.4K
Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
2.4K
01:30Adrenergic Agonists: Therapeutic Uses
764
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
764
01:26Adrenergic Receptors: β Subtype
1.6K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
1.6K
01:30Adrenergic Agonists: Direct-Acting Agents
1.4K
Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
These agents can be classified...
These agents can be classified...
1.4K
02:06Allergic Reactions
27.3K
Overview
27.3K