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Updated: Jun 21, 2025
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Simultaneous Affinity Enrichment of Two Post-Translational Modifications for Quantification and Site Localization
Published on: February 27, 2020
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Lactylation: The emerging frontier in post-translational modification.
Zhou Lu1, Xueting Zheng1, Mingsong Shi1
1NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Frontiers in Genetics
|July 12, 2024
Summary
Lactate is a key signaling molecule. Lactylation, a modification by lactate, impacts cell functions, but its mechanisms require further study for disease insights.
Area of Science:
- Biochemistry
- Molecular Biology
- Cellular Metabolism
Background:
- Lactate, a metabolic byproduct, is increasingly recognized as a critical signaling molecule.
- Lactylation, a post-translational modification, influences diverse cellular processes including inflammation, development, and cancer.
Purpose of the Study:
- To provide a comprehensive overview of lactylation.
- To elucidate the molecular mechanisms of lactylation in physiological and pathological conditions.
- To identify research gaps and future directions in lactylation studies.
Main Methods:
- Literature review of lactylation.
- Analysis of protein lactylation across organisms.
- Summary of regulatory mechanisms in cellular processes and diseases.
Main Results:
- Lactylation is a significant post-translational modification with broad biological implications.
- The regulatory networks and disease-specific roles of lactylation are complex and multifaceted.
- Existing research highlights numerous unanswered questions regarding lactylation's precise functions.
Conclusions:
- Further investigation into lactylation mechanisms is crucial for understanding cellular functions and diseases.
- Identifying specific lactylation targets and pathways will advance therapeutic strategies.
- Future research should focus on the dynamic regulation and functional consequences of lactylation.
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