The Risk of Infection-Caused Mortality in Gastric Adenocarcinoma: A Population-Based Study
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View abstract on PubMed
Summary
This summary is machine-generated.Older gastric adenocarcinoma patients, especially males not receiving chemotherapy or surgery, face higher infection mortality risks. Early intervention for these factors is crucial for improving survival outcomes.
Area Of Science
- Oncology
- Epidemiology
- Medical Statistics
Background
- Gastric adenocarcinoma (GAC) is a significant cause of cancer mortality.
- Postoperative complications, particularly infections, adversely impact GAC prognosis and survival.
- Limited understanding exists regarding perioperative complications and their associated risk factors in GAC patients.
Purpose Of The Study
- To identify modifiable and non-modifiable risk factors for perioperative complications in gastric adenocarcinoma patients.
- To analyze the impact of these risk factors on infection-related mortality and overall survival.
- To inform targeted interventions for high-risk GAC patient populations.
Main Methods
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database for patient data extraction.
- Employed statistical analyses including Pearson's Chi-square, Cox regression, Kaplan-Meier, and binary regression.
- Analyzed data from 59,580 identified Gastric Adenocarcinoma patients.
Main Results
- Infectious mortality risk was significantly higher in patients aged ≥ 50 years (HR: 3.137), those not receiving chemotherapy (HR: 1.669) or surgery (HR: 1.412), and unstaged patients (HR: 1.699).
- Conversely, female (HR: 0.658) and married patients (HR: 0.627) exhibited lower mortality risks.
- Higher infection probability was observed in older patients (OR: 2.094), certain racial groups, specific tumor locations (lesser curvature, NOS), and patients not receiving chemotherapy (OR: 1.258).
Conclusions
- Older, unmarried males with GAC are identified as a high-risk group for infection-related mortality.
- Patients not undergoing chemotherapy or surgery face elevated risks.
- Special attention and tailored treatment strategies are recommended for these vulnerable GAC patient subgroups to mitigate mortality.
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