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Related Concept Videos

Assessing Body Temperature - Temporal Artery01:19

Assessing Body Temperature - Temporal Artery

538
Here is a stepwise guide to assessing the body temperature at the temporal artery using a temporal artery thermometer
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.  
Step 3: Assess the patient's...
538
Increased Body Temperature01:25

Increased Body Temperature

652
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
652
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

909
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
909
Assessing Body Temperature - Axilla01:14

Assessing Body Temperature - Axilla

580
Procedural Guide for Assessing Axillary Body Temperature using a Digital Thermometer:
Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
Step 3: Adjust the patient’s clothing to expose only the axilla. It minimizes...
580
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

119
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
119
Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

932
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
932

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Updated: Jun 21, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
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Can Hyperthermia Unveil Brugada Pattern?

Poornima Vinod1, Hiten Patel2

  • 1Department of Internal Medicine, University of North Carolina Health at Southeastern, Lumberton, NC 28358, USA.

Journal of Medical Cases
|July 12, 2024
PubMed
Summary
This summary is machine-generated.

Hyperthermia can unmask Brugada electrocardiography (EKG) pattern, a condition linked to sudden cardiac death. Prompt fever management resolves these EKG changes, preventing life-threatening arrhythmias.

Keywords:
Brugada syndromeElectrocardiography findingsHyperthermiaSudden cardiac deathVentricular arrhythmias

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Area of Science:

  • Cardiology
  • Clinical Electrophysiology

Background:

  • Brugada syndrome (BrS) is a genetic disorder characterized by specific EKG abnormalities and an increased risk of sudden cardiac death (SCD).
  • The Brugada EKG pattern involves ST-segment elevations in right precordial leads (V1-V3), often associated with ventricular arrhythmias.

Observation:

  • A case study highlights hyperthermia as a trigger that unveiled the Brugada EKG pattern.
  • The study observed the resolution of these electrocardiographic findings upon effective management of the patient's fever.

Findings:

  • Hyperthermia can unmask a Brugada electrocardiography (EKG) pattern.
  • Appropriate management of hyperthermia led to the resolution of Brugada EKG findings.
  • Distinguishing the Brugada EKG pattern from other causes of ST elevation is critical for preventing ventricular fibrillation and SCD.

Implications:

  • Identifying environmental triggers like fever is crucial for managing patients with Brugada EKG pattern.
  • Prompt fever treatment with antipyretics and avoidance of sodium channel blockers during febrile episodes are vital.
  • Genetic testing and family screening are recommended for patients diagnosed with Brugada syndrome.