Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Early Monitoring Values Of Oncogenic Signalling Molecules For Hepatocellular Carcinoma

Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

Min Yao1, Rong-Fei Fang2, Qun Xie3

  • 1Department of Immunology, Medical School of Nantong University and Research Center of Clinical Medicine, The Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.

World Journal of Gastrointestinal Oncology
|July 12, 2024

Related Experiment Videos

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.2K
Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids
07:25

Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids

Published on: August 18, 2023

1.6K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.5K

View abstract on PubMed

Summary
This summary is machine-generated.

Early detection of liver cancer is crucial. This review highlights novel signaling molecules, like high mobility group-Box 3 and glypican-3, as promising biomarkers for monitoring hepatocarcinogenesis and potential therapeutic targets.

Area of Science:

  • Hepatology
  • Oncology
  • Biomarker Discovery

Background:

  • Liver cancer prevention and early diagnosis present significant global health challenges.
  • Malignant transformation of hepatocytes involves the expression and secretion of various oncogenic signaling molecules into the bloodstream.
  • These molecules originate from diverse signaling pathways and play roles in cancer development and progression.

Purpose of the Study:

  • To review recent advancements in identifying and studying signaling molecules as sensitive biomarkers for monitoring liver cancer development (hepatocarcinogenesis).
  • To explore the potential of these molecules as early diagnostic indicators for hepatocellular carcinoma.
  • To discuss their utility as specific targeted therapy molecules for liver cancer.

Main Methods:

Keywords:
Cell signalsEarly diagnosisHepatocarcinogenesisSpecific biomarkers

Related Experiment Videos

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.2K
Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids
07:25

Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids

Published on: August 18, 2023

1.6K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.5K
  • Literature review of recent scientific studies on oncogenic signaling molecules in hepatocarcinogenesis.
  • Analysis of signaling molecules expressed during malignant transformation of hepatocytes.
  • Evaluation of secreted molecules in blood as potential biomarkers.

    • Main Results:

    • Several signaling molecules, including high mobility group-Box 3, angiopoietin-2, Golgi protein 73, glypican-3, Wnt3a, and secretory clusterin, are implicated in hepatocarcinogenesis.
    • These molecules show potential as sensitive biomarkers for early diagnosis of liver cancer.
    • They may also serve as targets for hepatocellular carcinoma therapy.

    Conclusions:

    • Novel signaling molecules represent a promising avenue for improving early liver cancer detection.
    • Further research into these biomarkers could lead to enhanced diagnostic tools and targeted treatment strategies for hepatocellular carcinoma.
    • Understanding the role of these molecules in hepatocarcinogenesis is key to advancing liver cancer management.