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Urinary Bladder

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

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Updated: Jun 21, 2025

Culture, Manipulation, and Orthotopic Transplantation of Mouse Bladder Tumor Organoids

Culture, Manipulation, and Orthotopic Transplantation of Mouse Bladder Tumor Organoids

Published on: January 31, 2020

What is a Bladder Cancer Molecular Subtype?

Mattias Höglund¹

¹Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden.

Bladder Cancer (Amsterdam, Netherlands)

|July 12, 2024

Summary

Defining molecular subtypes for bladder cancer requires clear assumptions. Different approaches yield varied classifications, highlighting the need for consistent methodology in bladder cancer research.

Area of Science:

Oncology
Molecular Biology
Cancer Research

Background:

Molecular classification systems for bladder cancer are numerous.
Discrepancies in defining molecular subtypes cause confusion.
Standardization is needed for accurate bladder cancer subtyping.

Purpose of the Study:

To analyze various aspects of bladder cancer molecular classification.
To explore the impact of different conceptual frameworks.
To critically evaluate assumptions in defining molecular subtypes.

Main Methods:

Critical reflection on principles and methodologies.
Analysis of conceptual approaches in subtype definition.
Examination of underlying assumptions in molecular classification.

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Culture, Manipulation, and Orthotopic Transplantation of Mouse Bladder Tumor Organoids

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Published on: March 29, 2019

Main Results:

The definition of molecular subtypes is contingent on underlying assumptions and objectives.
Different approaches lead to distinct molecular subtype classifications.
Variability in subtype definitions impacts bladder cancer research.

Conclusions:

Clarification of underlying assumptions is crucial for defining molecular subtypes.
Understanding the consequences of different conceptual approaches is essential.
Standardized methods for molecular subtyping will improve bladder cancer diagnosis and treatment.