Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multicenter evaluation of six methods for predicting warfarin maintenance-dose requirements from initial response.

W T Sawyer, T E Poe, B R Canaday

    Clinical Pharmacy
    |July 1, 1985
    PubMed
    Summary

    Warfarin maintenance doses can be accurately predicted using initial prothrombin time (PT) measurements. This method helps optimize warfarin dosing for patients, ensuring therapeutic effectiveness and safety.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Within-category similarity negatively affects associative memory performance in both younger and older adults.

    Memory (Hove, England)·2022
    Same author

    Postoperative cognitive dysfunction and dementia: what we need to know and do.

    British journal of anaesthesia·2017
    Same author

    Oral health needs assessment world-wide in relation to HIV. Themes: Oral health needs and inequalities, oral health promotion, co-ordinating research and enhancing dissemination in relation to HIV- a workshop report.

    Oral diseases·2016
    Same author

    Hyderabad declaration 2014.

    Oral diseases·2016
    Same author

    Effects of Cohabitation on the Population Performance and Survivorship of the Invasive Mosquito Aedes albopictus and the Resident Mosquito Aedes notoscriptus (Diptera: Culicidae) in Australia.

    Journal of medical entomology·2015
    Same author

    Histone deacetylase inhibition protects hearing against acute ototoxicity by activating the Nf-<i>κ</i>B pathway.

    Cell death discovery·2015

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Internal Medicine

    Background:

    • Warfarin dosing requires careful management to maintain therapeutic anticoagulation.
    • Predicting maintenance doses early can improve patient outcomes and reduce monitoring burden.

    Purpose of the Study:

    • To compare six mathematical methods for predicting warfarin maintenance-dose requirements based on initial therapy response.
    • To evaluate the accuracy of these prediction methods against actual patient dose requirements.

    Main Methods:

    • A multicenter trial involving patients receiving an initial warfarin regimen of 10 mg daily for three days.
    • Prothrombin time (PT) and prothrombin ratios (PRs) were measured 16-20 hours after the third dose.
    • Six mathematical models were used to predict maintenance doses, with five utilizing day 4 PRs.

    Related Experiment Videos

    Main Results:

    • Dose predictions using prothrombin ratios correlated significantly with actual maintenance dose requirements for patients within the therapeutic range.
    • The formula Dose = 11.17 - 21.08 (log PR) provided the closest prediction to actual doses.
    • The mean actual warfarin maintenance dose for therapeutic response was 7.6 mg/day.

    Conclusions:

    • Initial warfarin maintenance-dose requirements can be effectively predicted using a single PT determination after three days of standard dosing.
    • Mathematical models based on early prothrombin ratio response offer a reliable method for dose prediction.