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Biological functions and potential mechanisms of miR‑143‑3p in cancers (Review)

Jia Wu1, Ying Zhu1, Dandan Liu1

  • 1Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.

Oncology Reports
|July 12, 2024
PubMed

Insights

MicroRNA-143-3p (miR-143-3p) is often downregulated in cancers and impacts tumor progression. This review details miR-143-3p

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are increasingly recognized for their roles in cancer development and as potential biomarkers.
  • miR-143-3p, a mature miRNA derived from pre-miRNA-143, is frequently downregulated in various malignant tumors.
  • Existing research highlights miR-143-3p's involvement in cancer progression, but a comprehensive review is lacking.

Purpose of the Study:

  • To systematically review the biogenesis, biological functions, and mechanisms of miR-143-3p in different cancer types.
  • To elucidate the role of miR-143-3p in cancer progression and its regulation by upstream factors.
  • To highlight the potential of miR-143-3p as a cancer biomarker and suggest future research directions.

Main Methods:

  • Comprehensive literature review of studies on miR-143-3p and its role in cancer.
  • Analysis of signaling pathways regulated by miR-143-3p, including PI3K/Akt, Wnt/β-catenin, AKT/STAT3, and Ras-Raf-MEK-ERK.
  • Synthesis of data on miR-143-3p expression levels, target genes, and functional impacts across various cancers.

Main Results:

  • miR-143-3p is consistently downregulated in most malignant tumors, suggesting a tumor-suppressive role.
  • miR-143-3p regulates target genes involved in cancer progression through multiple key signaling pathways.
  • Evidence supports miR-143-3p's involvement in the biological processes of diverse cancer types.

Conclusions:

  • miR-143-3p plays a significant role in cancer progression and exhibits potential as a diagnostic and prognostic biomarker.
  • Understanding the regulatory network of miR-143-3p offers insights into novel therapeutic strategies for cancer.
  • Further research is warranted to fully explore the clinical utility and therapeutic applications of miR-143-3p.
Keywords:
biomarkercancermechanismmicroRNA‑143‑3ptherapy

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