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Updated: Jun 21, 2025
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Self-Administration of Drugs in Mouse Models of Feeding and Obesity
Published on: June 8, 2021
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Psychotropic drugs, eating behaviour and weight gain
Shalika Arniotis-Streat1, Anthony Fonte1, Hisham Ziauddeen1,2
1Mental Health service, Fiona Stanley Fremantle Hospitals Group, Murdoch, WA, Australia.
Current Opinion in Psychiatry
|July 12, 2024
Summary
Psychotropic drug-related weight gain (PDWG) is often caused by increased calorie intake due to altered eating behaviors. Monitoring these changes can help prevent or treat PDWG early.
Area of Science:
- Pharmacology
- Psychiatry
- Nutrition Science
Background:
- Psychotropic drug-related weight gain (PDWG) is a significant concern for patients and clinicians.
- Preventive and early treatment strategies for PDWG are increasingly recommended.
- Altered eating behavior is a primary mechanism driving PDWG through increased caloric intake.
Purpose of the Study:
- To review the impact of psychotropic medications on eating behavior.
- To highlight the role of altered eating behavior as an early indicator of PDWG risk.
- To emphasize the clinical utility of monitoring eating behavior changes.
Main Methods:
- Systematic reviews and meta-analyses were examined.
- Prevalence and nature of eating behavior alterations were assessed.
- Association between specific psychotropic agents and eating behavior changes was analyzed.
Main Results:
- Psychotropic treatments can lead to increased hunger, night eating, and binge eating.
- These eating behavior alterations are more pronounced with agents like olanzapine and clozapine.
- Altered eating behavior is a common and measurable side effect.
Conclusions:
- Altered eating behavior serves as an early marker for PDWG risk.
- Clinical monitoring of eating behavior changes is feasible and valuable.
- Early detection enables timely interventions, including treatment modification and preventive strategies.
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