Related Experiment Video

Updated: Jun 21, 2025

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
09:14

An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay

Published on: January 26, 2019

10.8K

Passive Immunization Strategies to Prevent Severe Respiratory Syncytial Virus Infection Among Newborns and Young

Manika Suryadevara1

  • 1Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York 13210, USA.

Journal of the Pediatric Infectious Diseases Society
|July 12, 2024
PubMed

Insights

Maternal immunization and antibody administration offer crucial protection for newborns against severe respiratory syncytial virus (RSV) lower respiratory tract infections. These passive immunity strategies are vital for infant health and preventing serious illness.

Area of Science:

  • Immunology
  • Pediatrics
  • Virology

Background:

  • Newborns and young infants face significant risks from severe respiratory syncytial virus (RSV) lower respiratory tract infections.
  • Passive immunity, primarily through transplacental antibody transfer, is the primary method for preventing RSV in this vulnerable population.
  • Factors like gestational age, birth weight, and maternal health influence the efficacy of antibody transfer.

Purpose of the Study:

  • To review the mechanisms and effectiveness of passive immunity for protecting newborns and young infants against RSV.
  • To highlight the role of maternal immunization and direct antibody administration in preventing severe RSV disease.
  • To underscore the importance of RSV-neutralizing antibodies for infant protection.

Main Methods:

  • Review of existing literature on passive immunity against RSV in neonates and infants.
  • Analysis of factors affecting transplacental antibody transfer.
  • Evaluation of the impact of maternal RSV vaccination and infant antibody administration on disease prevention.

Main Results:

  • Transplacental transfer of maternal antibodies provides initial protection but is influenced by various maternal and infant factors.
  • Maternal RSV immunization has been developed and approved, demonstrating efficient transfer of protective antibodies.
  • Direct administration of RSV-specific antibodies to infants achieves high serum titers, enhancing protection against severe RSV disease.

Conclusions:

  • Passive immunization strategies, including maternal vaccination and infant antibody administration, are effective in protecting newborns and young infants from severe RSV infections.
  • Ensuring adequate levels of RSV-neutralizing antibodies is critical for preventing life-threatening respiratory illness in the youngest populations.
  • Continued research and application of these methods are essential for safeguarding infant health against RSV.

Keywords:
RSVmaternal vaccinationmonoclonal antibodiespassive immunityrespiratory syncytial virus

More Related Videos

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

15.6K
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

7.9K

Related Concept Videos

Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.0K
Active versus Passive Immunity01:31

Active versus Passive Immunity

Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
617
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
300
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
397
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
129