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RSV Prevention Within Reach for Older Infants and Toddlers: The Role of Active Immunization

Asuncion Mejias1,2, Octavio Ramilo1,2

  • 1Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Journal of the Pediatric Infectious Diseases Society
|July 12, 2024
PubMed

Insights

New vaccines and monoclonal antibodies are being evaluated to prevent respiratory syncytial virus (RSV) disease in young children. This review covers passive immunity for infants and active immunization strategies using various vaccine types.

Area of Science:

  • Pediatrics
  • Immunology
  • Infectious Diseases

Background:

  • Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in infants and young children.
  • Current prevention strategies are limited, highlighting the need for novel interventions.

Purpose of the Study:

  • To review current vaccines and monoclonal antibodies under investigation for RSV prevention in young children.
  • To discuss the scientific rationale for passive and active immunization against RSV.

Main Methods:

  • Literature review of ongoing clinical trials and research on RSV prevention.
  • Analysis of different vaccine platforms including live attenuated, protein-based, and mRNA vaccines.
  • Evaluation of monoclonal antibodies for passive protection.

Main Results:

  • Several promising vaccines and monoclonal antibodies are in development for RSV.
  • Passive immunization offers protection in early infancy, while active immunization targets older children.
  • Diverse vaccine technologies are being explored for efficacy and safety.

Conclusions:

  • Multiple novel strategies are emerging for RSV prevention in pediatric populations.
  • A combination of passive and active immunization may be necessary for comprehensive RSV control.
  • Continued research is crucial to bring these preventative measures to fruition.

Keywords:
RSVmonoclonal antibodypreventionstoddlersvaccines

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