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Use of Cefiderocol in Adult Patients: Descriptive Analysis from a Prospective, Multicenter, Cohort Study.
Daniele Roberto Giacobbe1,2, Laura Labate3, Chiara Russo Artimagnella3,4
1Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. danieleroberto.giacobbe@unige.it.
Infectious Diseases and Therapy
|July 12, 2024
Summary
Cefiderocol is primarily used for targeted therapy against carbapenem-resistant Gram-negative bacteria (CR-GNB), but also in over 25% of empirical treatments. Further research is needed to compare cefiderocol monotherapy versus combination therapy efficacy.
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Microbiology
Background:
- Cefiderocol exhibits activity against carbapenem-resistant Gram-negative bacteria (CR-GNB).
- Limited real-world data exist on cefiderocol's therapeutic strategies, indications, and patient profiles.
Purpose of the Study:
- To describe the real-world utilization of cefiderocol.
- To analyze therapy types, indications, and patient characteristics associated with cefiderocol use.
Main Methods:
- Multicenter, prospective study.
- Involved 200 patients receiving cefiderocol.
- Descriptive analysis of therapy types (empirical/targeted, monotherapy/combination) and patient factors.
Main Results:
- Cefiderocol was used in targeted (72.5%) and empirical (27.5%) therapies.
- Monotherapy (50.5%) and combination therapy (49.5%) were similarly distributed.
- Factors associated with combination therapy included previous CR-AB isolation and HSCT; CKD was linked to monotherapy.
- 30-day mortality varied by pathogen, with highest rates in A. baumannii infections.
Conclusions:
- Cefiderocol is predominantly used for targeted treatment, but empirical use necessitates standardized guidelines.
- The balanced use of monotherapy and combination therapy highlights the need for comparative efficacy studies.
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