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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Ruthenium-Catalyzed Sequential Hydrosilylation/Dehydrogenation and C-H Silylation: Synthesis of Six-Membered Indole
Jiefang Li1, Shanshan Xu1, Jieyu Liang1
1School of Environmental and Chemical Engineering, Wuyi University, Jiangmen, Guangdong 529020, People's Republic of China.
Abstract:
Selective dehydrogenative C-H silylation is one of the most powerful tools to synthesize silacycles. Herein, we developed Ru-catalyzed sequential hydrosilylation/C-H silylation of allyl-indoles and dehydrogenative O-H/C-H silylation of pyrrole phenols. Both six-membered indole silacycles and pyrrole silyl ether cycles were successfully synthesized with good functional group tolerance. Furthermore, the RuHCl(CO)(PPh3)3 catalyst exhibited high reaction compatibility in hydrosilylation of alkene, dehydrogenative O-H silylation, and C-H silylation.
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