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Updated: Aug 19, 2026

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells
14:22

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells

Published on: July 16, 2011

[Interrelation of erythropoiesis and lymphopoiesis in experimental infectious processes and in viral leukemogenesis]

A V Sanin, A E Snegireva, T N Nikolaeva

    Eksperimental'Naia Onkologiia
    |January 1, 1985
    PubMed

    Insights

    Infectious agents like Rauscher leukemia virus and certain bacteria can boost red blood cell production (erythropoiesis) while suppressing the immune response. This inverse relationship highlights complex host-pathogen interactions.

    Area of Science:

    • Immunology
    • Hematology
    • Microbiology

    Context:

    • Investigates the complex interplay between erythropoiesis and immune responses.
    • Utilizes mouse models infected with Mycoplasma species, Shigella flexneri 2a, and Rauscher leukemia virus (R-MLV).
    • Assesses erythropoiesis via endocolonization and 59Fe incorporation, and immune reactivity through splenic antibody-forming cells.

    Purpose:

    • To elucidate the relationship between erythropoiesis and immune function during infection.
    • To determine if infectious agents differentially affect these two physiological processes.
    • To explore the correlation between erythropoiesis enhancement and immune suppression.

    Summary:

    • Found an inverse correlation: agents enhancing erythropoiesis tended to depress immune reactivity.
    • Rauscher leukemia virus and specific Mycoplasma/Shigella strains showed enhanced erythropoiesis with diminished immune response.
    • A positive correlation existed between erythropoiesis activation by microbes and their stimulation of R-MLV reproduction.

    Impact:

    • Suggests a potential role for mononuclear phagocytes in mediating these observed phenomena.
    • Provides insights into host-pathogen dynamics affecting both blood cell production and immunity.
    • Offers a basis for understanding how certain infections can compromise immune defenses through erythropoiesis modulation.

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