Ichthyosis uteri complicated by endometrial adenocarcinoma with transitional cell differentiation: A case report
Liya Ding1, Wangwang Liu1, Hui Li1
1Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China.
Rationale:
Ichthyosis uteri is a rare pathological condition characterized by the replacement of the endometrial lining by stratified squamous epithelium. Yet its occurrence with endometrial adenocarcinoma is very rare.
Patient Concerns:
A 68-year-old woman has been experiencing sporadic, minor vaginal hemorrhages for a few months. The gynecological evaluation revealed a uterine enlargement and imaging demonstrated an irregular mass within the uterus.
Diagnosis:
Endometrial adenocarcinoma with transitional cell differentiation; ichthyosis uteri with dysplasia.
Interventions:
Radical hysterectomy with pelvic lymphadenectomy was performed followed by postoperative radiotherapy.
Outcomes:
Postoperative follow-up at 8 months showed a favorable outcome without signs of recurrence and metastasis.
Lessons:
Adequate pathological sampling is crucial to identifying the accompanying lesions of ichthyosis uteri. Finding molecular alterations in various pathological morphologies is important to understand the evolution of disease.
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