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Updated: Jun 21, 2025

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
The Total Synthesis of Hyperfirin via a Cyclooctadiene Strategy
Julien A König1, Bernd Morgenstern2, Johann Jauch1
1Organic Chemistry II, Saarland University, 66123 Saarbrücken, Germany.
Abstract:
Polycyclic polyprenylated acylphloroglucinols (PPAPs) combine compelling structural complexity with effective biological activity. The total synthesis of Hyperfirin is reported as one linear sequence. Key to this novel modular strategy is to access the bicyclo[3.3.1]nonane-2,4,9-trione framework via transannular acylation of a decorated eight-membered ring, followed by late stage bridgehead substitution. The described route adds flexibility to PPAP construction and broadens the scope of eight-membered ring chemistry.
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