Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

435
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
435
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bayesian Optimization of Catalysis with In-Context Learning.

ACS central science·2026
Same author

A multi-agent system for automating scientific discovery.

Nature·2026
Same author

Huge analysis of 320,000 careers suggests that productive researchers stay that way.

Nature·2026
Same author

MDCrow: automating molecular dynamics workflows with large language models.

Machine learning: science and technology·2026
Same author

Now is the time for scientific societies to guide global research.

Nature·2026
Same author

A mu-opioid receptor positive allosteric modulator provides opioid-sparing antinociception without enhancing opioid side effects.

The Journal of pharmacology and experimental therapeutics·2026

Related Experiment Video

Updated: Jun 21, 2025

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

8.7K

Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting

Zhicheng Le1, Mayk Caldas Ramos2, Yufeng Shou3

  • 1Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore; Institute of Health Innovation & Technology, National University of Singapore, Singapore, 117599, Singapore.

Biomaterials
|July 12, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel microneedle system using sucralfate and interleukin-4 to accelerate wound healing by enhancing cell regeneration and growth factor stability.

Keywords:
BioactiveGrowth factorsMicroneedleSucralfateWound healing

More Related Videos

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:23

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

248
Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device
04:04

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Published on: December 27, 2024

503

Related Experiment Videos

Last Updated: Jun 21, 2025

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

8.7K
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:23

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

248
Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device
04:04

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Published on: December 27, 2024

503

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Impaired wound healing, often due to poor cell proliferation and angiogenesis, presents a global health challenge.
  • Current therapeutic growth factor delivery methods are limited by poor stability in wound environments.

Purpose of the Study:

  • To develop a two-stage microneedle strategy for enhanced wound healing using sucralfate and interleukin-4.
  • To investigate the synergistic mechanisms of this delivery system in promoting tissue repair.

Main Methods:

  • Utilized bioactive sucralfate-based microneedles (SUC-MN) for controlled delivery of interleukin-4 (IL-4).
  • Investigated the reprogramming of M2-like macrophages via the JAK-STAT pathway.
  • Assessed the impact of sucralfate on growth factor stability and bioavailability.
  • Evaluated wound healing acceleration in diabetic mice and porcine models.

Main Results:

  • The IL-4/SUC-MN system significantly enhanced endogenous growth factor production by reprogramming macrophages.
  • Sucralfate improved growth factor stability, increasing their bioavailability in the wound.
  • Accelerated wound healing by 56.6% in diabetic mice and 46.5% in porcine models compared to controls.

Conclusions:

  • The developed IL-4/SUC-MN technology offers a promising strategy for accelerating wound healing.
  • This approach leverages synergistic mechanisms, including enhanced macrophage polarization and improved growth factor stability.
  • Molecular simulations can guide the identification of bioactive ingredients for advanced wound care applications.