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Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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Related Experiment Video

Updated: Apr 30, 2026

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite

Published on: February 16, 2016

Brief guidelines for zebrafish embryotoxicity tests.

Taeyeon Hong¹, Junho Park², Gwonhwa Song²

¹Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Molecules and Cells

|July 12, 2024

Summary

This summary is machine-generated.

This study outlines essential guidelines for using zebrafish in environmental pollutant toxicity research. It covers zebrafish care, breeding, toxicant exposure, and monitoring for adverse effects, aiding future ecotoxicology studies.

Keywords:

Embryo Morphological change Survival rate Toxicology Zebrafish

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Last Updated: Apr 30, 2026

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite

Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite

Published on: February 16, 2016

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos

Published on: August 25, 2019

Small Molecule Screening and Toxicity Testing in Early-stage Zebrafish Larvae

Small Molecule Screening and Toxicity Testing in Early-stage Zebrafish Larvae

Published on: March 7, 2025

Area of Science:

Environmental Science
Toxicology
Ecotoxicology

Background:

Environmental pollution from heavy metals, pesticides, and nanoplastics is a growing global concern.
Numerous toxicities associated with these pollutants have been documented.
Zebrafish are a valuable animal model for environmental toxicity studies due to their advantages.

Conclusions:

Zebrafish offer a robust model for assessing the toxic impacts of environmental pollutants.
Standardized guidelines are crucial for reliable ecotoxicology research.
This work facilitates further investigation into the environmental health risks of pollutants.