Related Experiment Video
Updated: Jun 21, 2025
05:23
Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
304
Helicobacter pylori eradication therapy for children
Kairat Rysbekov1, Sagira Abrakhmanova1, Rashida Satybaeva1
1Department of Pediatric Diseases with Courses Cardio-Rheumatology and Gastroenterology, 217968 Astana Medical University , Astana, Kazakhstan.
Drug Metabolism and Personalized Therapy
|July 12, 2024
Summary
Vitamin D supplementation did not improve Helicobacter pylori eradication rates when added to standard triple therapy. The study found no significant increase in treatment efficacy with vitamin D inclusion.
Area of Science:
- Pediatrics
- Infectious Diseases
- Gastroenterology
Background:
- * Helicobacter pylori (H. pylori) infection is a common cause of gastrointestinal issues in children.
- * Standard triple therapy is the primary treatment for H. pylori eradication.
- * Vitamin D's role in H. pylori eradication is not well-established.
Purpose of the Study:
- * To evaluate the impact of vitamin D supplementation on H. pylori eradication therapy success rates.
- * To explore potential new drug combinations for H. pylori eradication.
Main Methods:
- * A controlled study involving 128 children diagnosed with H. pylori infection.
- * Group A received standard triple therapy plus vitamin D; Group B received standard triple therapy alone.
- * Vitamin D levels were measured, and eradication success was assessed 45 days post-treatment.
Main Results:
- * The overall H. pylori eradication success rate was 84.1%.
- * Group A (with vitamin D) achieved a 93.5% success rate, while Group B (without vitamin D) had a 75% success rate.
- * The difference in eradication rates between groups A and B was not statistically significant (p=0.082).
Conclusions:
- * Adding vitamin D to standard triple therapy for H. pylori eradication in children did not significantly enhance treatment efficacy.
- * Vitamin D supplementation does not appear to be a beneficial adjunct to current H. pylori eradication regimens.
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