Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
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View abstract on PubMed
Summary
This summary is machine-generated.Helicobacter pylori infection promotes gastric cancer by increasing ONECUT2, which enhances cancer stemness. Targeting ONECUT2 may offer a new therapeutic strategy for Helicobacter pylori-associated gastric cancer.
Area Of Science
- Oncology
- Gastroenterology
- Molecular Biology
Background
- Helicobacter pylori (HP) infection is a key driver of gastric carcinogenesis.
- ONECUT2 is implicated in tumor progression and presents potential for therapeutic targeting in gastric cancer (GC).
Purpose Of The Study
- To investigate the role of ONECUT2 in HP infection-associated gastric carcinogenesis.
- To elucidate the molecular mechanism by which ONECUT2 promotes GC.
- To assess ONECUT2 as a potential therapeutic target for GC.
Main Methods
- Analysis of multidimensional data.
- In vitro and in vivo experiments to assess cell stemness and signaling pathways.
- NFκB pathway analysis.
- Assessment of PPP2R4, PP2A, AKT, and β-catenin activity.
- Clinical survival analysis.
Main Results
- HP infection upregulates ONECUT2 transcription via NFκB.
- ONECUT2 enhances GC cell stemness by inhibiting PPP2R4 transcription, reducing PP2A activity.
- This leads to increased AKT/β-catenin phosphorylation, promoting nuclear translocation and stemness gene transcription.
- High ONECUT2 expression correlates with poor prognosis in GC patients.
Conclusions
- ONECUT2 plays a critical role in HP infection-associated GC development by promoting cancer stemness.
- The PPP2R4/AKT/β-catenin signaling pathway is central to ONECUT2's mechanism.
- Targeting ONECUT2 presents a promising therapeutic strategy for HP-associated GC.
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