Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

533
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
533
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

718
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
718
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

152
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
152
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

628
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
628
Direct-Acting Cholinergic Agonists: Pharmacokinetics01:31

Direct-Acting Cholinergic Agonists: Pharmacokinetics

1.1K
Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
1.1K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Risk factors on the unintentional injuries among rural children aged 0-12 in Shaanxi province].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2013
Same author

Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment.

Depression and anxiety·2013
Same author

Current status and challenge of Human Parasitology teaching in China.

Pathogens and global health·2012
Same author

Molecular characterization of heterogeneous mesenchymal stem cells with single-cell transcriptomes.

Biotechnology advances·2012
Same author

Surgical treatment of ossification of the ligamentum flavum associated with dural ossification in the thoracic spine.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2012
Same author

Broadband focusing ultrasonic transducers based on dimpled LiNbO3 plate with inversion layer.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control·2012

Related Experiment Video

Updated: Jun 21, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.6K

Choline consumption reduces CVD risk via body composition modification.

Haomiao Wang1, Jinxin Lin2, Shitao Fan3

  • 1Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

Scientific Reports
|July 12, 2024
PubMed
Summary

Adequate dietary choline intake may reduce cardiovascular disease (CVD) risk, potentially by improving body composition. Choline metabolism pathways after stroke could offer new therapeutic targets.

More Related Videos

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

402
Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

6.1K

Related Experiment Videos

Last Updated: Jun 21, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.6K
Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

402
Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

6.1K

Area of Science:

  • Nutritional Science
  • Cardiovascular Research
  • Genetics

Background:

  • Conflicting research exists on the link between choline and cardiovascular disease (CVD).
  • Understanding choline's role in CVD is crucial for public health.
  • Dietary factors significantly influence cardiovascular health outcomes.

Purpose of the Study:

  • To investigate the association between dietary choline intake and CVD risk.
  • To explore the causal relationship using Mendelian randomization.
  • To elucidate the role of choline metabolism in CVD progression and severity.

Main Methods:

  • Retrospective cohort study (n=14,663) from NHANES (2013-2018).
  • Propensity score matching and restricted cubic splines for association analysis.
  • Two-sample Mendelian randomization and bioinformatics analysis of single-cell RNA-sequencing data.

Main Results:

  • Higher choline intake (quartiles 3 & 4) was associated with reduced stroke risk (ORs 0.72 & 0.54).
  • Choline and phosphatidylcholine showed negative causal effects on body fat and mass.
  • Altered choline metabolism pathways were linked to stroke prognosis.

Conclusions:

  • Appropriate dietary choline intake may protect against CVD, possibly via improved body composition.
  • Choline-mediated effects on body composition are a key finding.
  • Targeting choline metabolism pathways presents a potential therapeutic strategy for stroke.