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Related Experiment Video

Updated: Jun 21, 2025

Nanosponge Tunability in Size and Crosslinking Density

Nanosponge Tunability in Size and Crosslinking Density

Published on: August 4, 2017

Preparation of Microsponge Drug Delivery System (MSDDS) Followed by a Scale-Up Approach.

S Halder¹, U S Behera², S Poddar^3,4

¹Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India.

AAPS Pharmscitech

|July 12, 2024

Summary

Researchers developed novel 5-fluorouracil (5 FU) microspheres (MS) for dermal applications. Optimized formulation achieved high drug entrapment and sustained release, showing promise for pharmaceutical development.

Keywords:

5-fluorouracil Face-centred central composite design matrix Microsponge-incorporated gel and scale-up

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Last Updated: Jun 21, 2025

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Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Microspheres (MS) offer advantages for bioactive compound delivery due to their porous structure.
Gel-encased formulations are suitable for dermal applications, enhancing drug delivery.

Purpose of the Study:

To develop and optimize 5-fluorouracil (5 FU) loaded microspheres (MS) for dermal application.
To evaluate the physicochemical properties and drug release kinetics of the optimized MS formulation.

Main Methods:

Quasi-emulsion (w/o/w) solvent evaporation technique was employed for MS preparation.
Scanning Electron Microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), and Differential Scanning Calorimetry (DSC) were used for characterization.
Central Composite Design (CCD) was utilized for optimization of formulation parameters.

Main Results:

Optimized formulation yielded 63% with a mean particle size of 152 µm.
High drug entrapment efficiency of 76% was achieved.
Cumulative drug release of 74.24% within 8 hours demonstrated sustained release characteristics.

Conclusions:

The developed 5 FU MS formulation is suitable for dermal delivery, exhibiting favorable characteristics for pharmaceutical applications.
Optimization using CCD resulted in a robust formulation with high yield and efficient drug delivery.
Findings align with UN Sustainable Development Goals 3, 9, and 17, and G20 initiatives.