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Updated: Jun 21, 2025
Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
Published on: January 6, 2012
An altered uterine microbiota with endometrial hyperplasia
Xue Ying1, Gufeng Xu1, Huiyun Wang1
1Department of Ambulatory Surgery, Women's Hospital, Zhejiang University School of Medicine, China. 1 Xueshi Road, Hangzhou, Zhejiang, 310006, P.R. China.
Background:
Endometrial hyperplasia (EH) is a precursor to endometrial cancer, and the role of the microbiome in its development is unclear.
Results:
The present study investigated the uterine microbiome in patients with benign uterine conditions and endometrial hyperplasia. A significant structural shift in the uterine microbiome of patients with endometrial hyperplasia compared to those with benign conditions was found. Delftia, Serratia and Stenotrophomonas were significantly enriched in endometrial hyperplasia samples and associated with the presence of endometrial hyperplasia.
Conclusions:
The novel finding suggested that increased abundance of Delftia, Serratia and Stenotrophomonas is associated with the presence of endometrial hyperplasia. Further investigation is needed to determine the value of these microbes as biomarkers for endometrial hyperplasia.
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