Related Experiment Video
Updated: May 7, 2026

07:51
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
1.6K
Blepharoptosis and corneal epithelial thickness alterations, is there any relation?
Seyed Mohsen Rafizadeh1, Seyed Ali Sonbolestan2, Haniyeh Zeidabadinejad3
1Department of oculo-facial plastic and reconstructive Surgery, Eye Research Center, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
BMC Ophthalmology
|July 12, 2024
Summary
Blepharoptosis, or drooping eyelids, can alter corneal epithelial thickness, particularly thinning the superior cornea. This finding suggests lid position impacts corneal health.
Area of Science:
- Ophthalmology
- Corneal Science
- Epithelial Biology
Background:
- Blepharoptosis, a condition characterized by drooping upper eyelids, can affect ocular structures.
- Understanding the impact of eyelid position on the cornea is crucial for comprehensive eye care.
Purpose of the Study:
- To compare the corneal epithelial thickness map in eyes affected by blepharoptosis with their contralateral non-affected eyes.
Main Methods:
- Consecutive unilateral blepharoptosis patients underwent comprehensive ophthalmologic examinations.
- Anterior segment imaging using the Avanti RTVue-XR platform assessed corneal epithelial thickness.
- Corneal epithelial thickness maps of ptotic and non-ptotic eyes were systematically compared.
Main Results:
- Ptotic eyes exhibited significantly thinner corneal epithelium in superior, superior-temporal, and superior-nasal sectors.
- A slight thickening of the corneal epithelium was observed in the inferior-nasal sector of ptotic eyes.
- No significant correlation was found between corneal epithelial thickness differences and patient age, blepharoptosis type, duration, or MRD1 measurements.
Conclusions:
- Eyelid position in blepharoptosis influences the corneal epithelial thickness map.
- The lower position of the upper eyelid in ptosis may lead to a thinning effect on the superior corneal sectors.

