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Oncology And Carcinogenesis
Predictive And Prognostic Markers
Decreased Levels Of Ptcsc3 Promote The Deterioration Of Prostate Cancer And Affect The Prognostic Outcome Of Patients Through Sponge Mir-182-5p.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Decreased Levels Of Ptcsc3 Promote The Deterioration Of Prostate Cancer And Affect The Prognostic Outcome Of Patients Through Sponge Mir-182-5p.

Related Experiment Video

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Decreased levels of PTCSC3 promote the deterioration of prostate cancer and affect the prognostic outcome of patients through sponge miR-182-5p.

Lin Cheng¹, Shuhui Li², Deqi Jiang¹

¹Department of Urology Surgery, Shandong Provincial Third Hospital, No.12, Wuyingshan Middle Road, Tianqiao District, Jinan, Shandong, 250031, China.

|July 12, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Long non-coding RNA PTCSC3 (PTCSC3) is downregulated in prostate cancer, correlating with shorter survival. PTCSC3 targets miR-182-5p, suppressing tumor progression and offering a potential biomarker for prognosis.

Keywords:

PTCSC3 Prognosis Prostate cancer miR-182-5p

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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

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Published on: November 19, 2019

Area of Science:

Oncology
Molecular Biology
Biomarker Discovery

Background:

Prostate cancer incidence is rising, with poor prognosis.
Long non-coding RNAs (lncRNAs) are implicated in cancer development.
The role of PTCSC3 in prostate cancer requires further investigation.

Purpose of the Study:

Investigate PTCSC3 expression and its molecular mechanism in prostate cancer.
Determine PTCSC3's potential as a prognostic and therapeutic biomarker.

Main Methods:

Quantitative RT-qPCR for PTCSC3 levels in serum and cells.
Correlation analysis with clinical indicators and survival (Kaplan-Meier, Cox analysis).
Functional assays (CCK-8, Transwell) and bioinformatics/luciferase assays for PTCSC3-miR-182-5p interaction.

Main Results:

PTCSC3 is significantly downregulated in prostate cancer tissues and serum.
Low PTCSC3 levels correlate with shorter overall survival.
PTCSC3 suppresses prostate cancer cell proliferation, migration, and invasion by targeting miR-182-5p.

Conclusions:

PTCSC3 acts as a tumor suppressor in prostate cancer.
PTCSC3 may regulate prostate cancer progression by sponging miR-182-5p.
PTCSC3 is a potential prognostic biomarker for prostate cancer.