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Production of human interferon-beta in mouse L-cells
Developments in Biological Standardization
|January 1, 1985
Abstract:
A mouse fibroblast cell-constructed by genetic engineering--expresses glycosylated human interferon-beta constitutively. The cells were cultivated on microcarriers in special bioreactors. Under these conditions they produce a maximum yield of 6 000 units interferon-beta/ml/day at cell densities of about 2,2 X 10(6) cells/ml. The production stage of interferon-beta is longer than one month.