VNN1 Gene Expression and Polymorphisms Associated with Chicken Carcass Traits
Siyu Zhang1,2, Xiang Fang1,2, Ruiquan Wu1,2
1State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Animals : an Open Access Journal From MDPI
|July 13, 2024
Summary
This study links liver VNN1 gene expression and genetic variations to key carcass traits in Mahuang chickens, offering insights for poultry breeding. These findings support optimizing traits for market demands and slaughter efficiency.
Area of Science:
- Animal Genetics
- Poultry Science
- Molecular Biology
Background:
- The VNN1 gene plays a role in metabolic processes.
- Understanding genetic factors influencing carcass traits is crucial for poultry breeding programs.
Purpose of the Study:
- To investigate the association between hepatic VNN1 expression and carcass traits in Mahuang chickens.
- To identify polymorphisms in VNN1 regulatory regions potentially linked to carcass traits.
Main Methods:
- Gene expression analysis in chicken liver tissue.
- Polymorphism identification in upstream and downstream regions of the VNN1 gene.
- Statistical association analysis between genetic variations and carcass traits.
Main Results:
- Hepatic VNN1 expression levels correlated significantly with dressed weight, eviscerated weight, and abdominal fat weight.
- 39 polymorphic sites were identified in the VNN1 regions, with 23 associated with 15 carcass traits.
- Haplotype blocks (BLOCK2 and BLOCK3) showed associations with various weight and percentage traits, including thigh, breast muscle, and wing weight.
Conclusions:
- VNN1 is a significant genetic factor influencing carcass traits in Mahuang chickens.
- Identified polymorphisms and haplotype blocks provide genetic markers for selection.
- Findings can guide breeding strategies to enhance desirable carcass characteristics and improve slaughter efficiency.
Related Concept Videos
02:26Comparing Copy Number Variations and SNPs
17.7K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.7K
01:05Single Nucleotide Polymorphisms-SNPs
15.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.0K
02:41Lethal Alleles
15.4K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.4K
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
00:49Complementation Tests
4.9K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
4.9K