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Updated: Jun 21, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Recent Progress on Multi-Component Reactions Involving Nucleophile, Arynes and CO2
Shaoxuan Gong1, Xiumei Xie1, Hongxia Sun1
1Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant & School of Pharmacy, Chengdu University, Chengdu 610106, China.
Abstract:
Carbon dioxide (CO2) is a non-toxic, abundant and recoverable source of carbon monoxide. Despite its thermodynamically stable and kinetically inert nature, research on CO2 utilisation is ongoing. CO2-based aryne reactions, crucial for synthesising ortho-substituted benzoic acids and their cyclisation products, have garnered significant attention, and multi-component reactions (MCRs) involving CO2, aryne and nucleophilic reagents have been extensively studied. This review highlights recent advancements in CO2 capture reactions utilising phenylalkyne reactive intermediates. Mechanistic insights into these reactions are provided together with prospects for further development in this field.
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