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Published on: September 27, 2024
Association between Systolic Blood Pressure Variability and Incident Aortic Stenosis
Hyun-Jung Kim1, Ji-Eon Kim2, Jae-Seung Jung2
1Department of Preventive Medicine, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
High blood pressure variability (BPV) and hypertension are linked to increased aortic stenosis (AS) risk. Managing blood pressure stability is crucial for preventing AS incidence.
Area of Science:
- Cardiovascular Medicine
- Hypertension Research
- Epidemiology
Background:
- Investigates the association between blood pressure variability (BPV) and incident aortic stenosis (AS).
- Utilizes large-scale Korean National Health Insurance Service data from 2002-2019.
Purpose of the Study:
- To determine if systolic blood pressure variability (SBPV) is an independent predictor of aortic stenosis (AS).
- To assess the risk of AS associated with different levels of SBPV.
Main Methods:
- Collected annual SBPV from three consecutive readings over three years for over 9 million individuals.
- Categorized SBPV into five quantiles, with the highest representing significant blood pressure fluctuations.
- Performed survival analysis to evaluate the association between SBPV quintiles and incident AS.
Main Results:
- Higher SBPV was independently associated with an increased risk of AS.
- The highest quintile of SBPV showed a significantly elevated hazard ratio (HR) of 1.39 (p < 0.001) for AS incidence.
- Hypertension and elevated SBPV were identified as independent predictors for AS.
Conclusions:
- Elevated systolic blood pressure variability (SBPV) is a significant risk factor for incident aortic stenosis (AS).
- Maintaining stable blood pressure, alongside managing hypertension, is vital for AS prevention.
- Highlights the clinical importance of monitoring BPV in cardiovascular risk assessment.
Related Concept Videos
Measurement of Blood Pressure
Assessment of blood pressure in brachial artery(two-step method)
Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Sites for measruring blood pressure
The Brachial Artery: Primary Site for Blood Pressure Measurement
Blood Pressure
Assessment of blood pressure in brachial artery(one-step method)
Prepare for the Procedure:

