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Comorbidities, Clinical Presentation, Subtypes, and Treatment of HS Patients in Lithuania
Tadas Raudonis1,2, Austėja Šakaitytė3, Tomas Petras Vileikis1
1Clinic of Infectious Disease and Dermatovenereology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, M. K. Čiurlionio g. 21, 03101 Vilnius, Lithuania.
Insights
Hidradenitis suppurativa (HS) severity correlates with inflammatory and metabolic comorbidities. Biologic treatments significantly improved HS scores more than systemic antibiotics.
Area of Science:
- Dermatology
- Genetics
- Metabolic Disorders
Background:
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease.
- HS is associated with numerous comorbidities.
- Current management includes antibiotics, hormone therapy, immune modulators, surgery, and comorbidity treatment.
Purpose of the Study:
- To evaluate comorbidities in HS patients.
- To identify clinical presentation subtypes.
- To assess applied treatments for HS.
Main Methods:
- Utilized the European Hidradenitis Suppurativa Foundation Registry questionnaire.
- Evaluated patients at the Centre of Dermatovenereology, Vilnius University Hospital.
- Included 49 patients diagnosed with HS.
Main Results:
- 61.22% of patients had comorbidities.
- Strong positive correlations found between family history of inflammatory diseases and HS severity (Hurley stage).
- Metabolic comorbidities significantly correlated with HS severity (Hurley stage).
- Biologic treatment showed significant improvement in IHS4 scores (7.38 to 3.22, p < 0.05).
- Non-biologic treatment showed no significant improvement in IHS4 scores (6.21 to 5.42, p > 0.05).
Conclusions:
- Family history of inflammatory diseases and metabolic comorbidities are strongly linked to HS severity.
- Biologic therapy demonstrates superior efficacy in improving HS scores compared to systemic antibiotics.
Abstract:
Background: Hidradenitis suppurativa (HS) is a persistent, recurring skin inflammatory condition linked to various comorbidities. Management involves antibiotics, hormone therapy, immune-modulating drugs, surgery, and treatment of comorbidities. The objectives of the study were to assess the comorbidities, clinical presentation subtypes, and applied treatment of patients with HS. Methods: Patients with HS who visited the Centre of Dermatovenereology at Vilnius University Hospital Santaros Klinikos in Lithuania underwent evaluation based on the guidelines of the European Hidradenitis Suppurativa Foundation Registry questionnaire. Results: The study included 49 patients, and 61.22% (n = 30) had comorbidities. A strong positive correlation was found between a family history of inflammatory diseases (69.38% (n = 34)) and the severity of HS according to Hurley stage (r = 0.71 p < 0.05). A statistically significant correlation (r = 0.944, p = 0.02) was found between metabolic comorbidities and Hurley stage. Patients on biologic treatment had a mean IHS4 of 7.38 at the beginning of treatment and 3.22 at follow-up (p < 0.05). For patients not on biologics, the initial IHS4 score was 6.21 and 5.42 at follow-up (p > 0.05). Conclusions: A family history of inflammatory diseases and metabolic comorbidities showed a strong correlation with HS severity. Treatment with biologics showed significant improvement in HS scores compared to systemic antibiotics.
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