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Updated: Jun 21, 2025

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
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Hematopoietic Stem Cells and Their Niche in Bone Marrow

Munju Kwon1, Byoung Soo Kim2, Sik Yoon3

  • 1Department of Convergence Medicine, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.

International Journal of Molecular Sciences
|July 13, 2024
PubMed

Extensive research has explored the functional correlation between stem cells and progenitor cells, particularly in blood. Hematopoietic stem cells (HSCs) can self-renew and regenerate tissues within the bone marrow, while stromal cells regulate tissue function. Recent studies have validated the role of mammalian stem cells within specific environments, providing initial empirical proof of this functional phenomenon. The interaction between bone and blood has always been vital to the function of the human body. It was initially proposed that during evolution, mammalian stem cells formed a complex relationship with the surrounding microenvironment, known as the niche. Researchers are currently debating the significance of molecular-level data to identify individual stromal cell types due to incomplete stromal cell mapping. Obtaining these data can help determine the specific activities of HSCs in bone marrow. This review summarizes key topics from previous studies on HSCs and their environment, discussing current and developing concepts related to HSCs and their niche in the bone marrow.

Keywords:
bone marrow microenvironmenthematopoietic progenitor cellshematopoietic stem cellsniche

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