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SnoRNAs: Exploring Their Implication in Human Diseases.
Waseem Chauhan1, Sudharshan Sj1, Sweta Kafle1
1Department of Physiology, University of Tennessee Health Science Center, 71 S. Manassas St., Memphis, TN 38103, USA.
International Journal of Molecular Sciences
|July 13, 2024
Summary
Small nucleolar RNAs (snoRNAs) are key regulators of RNA modifications, impacting gene expression and human diseases. Their precise targeting ability offers potential as novel therapeutic agents for various pathologies.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Small nucleolar RNAs (snoRNAs) are non-coding RNAs involved in post-transcriptional RNA modifications.
- These modifications, including 2'-O-methylation and pseudouridylation, are essential for cellular function and gene regulation.
- Dysregulation of snoRNAs is implicated in various human diseases, including metabolic and non-metabolic pathologies.
Purpose of the Study:
- To review the critical roles of snoRNAs in RNA modification and gene expression.
- To explore the involvement of snoRNAs in human health and disease.
- To discuss the therapeutic potential of snoRNAs as molecular tools and agents.
Main Methods:
- Literature review of scientific articles on snoRNAs.
- Analysis of the functional mechanisms of snoRNAs in RNA modification.
- Examination of the link between snoRNAs and human diseases.
Main Results:
- SnoRNAs guide protein complexes (snoRNPs) to specific RNA sites for crucial modifications.
- These modifications are vital for ribosomal RNA synthesis and overall cellular operations.
- Aberrant snoRNA function is associated with the pathogenesis of diverse human diseases.
Conclusions:
- SnoRNAs play a fundamental role in maintaining cellular homeostasis and regulating gene expression.
- Their involvement in disease pathogenesis underscores their significance in human pathologies.
- SnoRNAs represent promising therapeutic targets and molecular tools for treating various diseases.
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