Breast Cancer: Extracellular Matrix and Microbiome Interactions
Lourdes Herrera-Quintana1,2, Héctor Vázquez-Lorente1,2, Julio Plaza-Diaz3,4,5
1Department of Physiology, Schools of Pharmacy and Medicine, University of Granada, 18071 Granada, Spain.
International Journal of Molecular Sciences
|July 13, 2024
Summary
This review explores the link between breast cancer, the extracellular matrix, and the microbiome. Understanding these interactions may reveal new therapeutic strategies for breast cancer treatment.
Area of Science:
- Oncology
- Microbiology
- Biochemistry
Background:
- Breast cancer is a leading cause of cancer mortality in women globally.
- Current treatments remain ineffective for patients with distant metastases.
- The extracellular matrix and microbiome are implicated in cancer progression.
Purpose of the Study:
- To review the current evidence on the relationship between breast cancer, extracellular matrix, and the microbiome.
- To discuss emerging associations and future perspectives in this field.
Main Methods:
- Literature review of existing research on breast cancer, extracellular matrix, and microbiome interactions.
- Synthesis of current evidence regarding tumorigenesis, invasion, and microbial dysbiosis in breast cancer.
Main Results:
- Extracellular matrix degradation and epithelial-mesenchymal transition are key to local invasion.
- Microbial dysbiosis is increasingly recognized as a factor in cancer development and progression.
- Interactions between the extracellular matrix and microbiome offer potential for novel breast cancer biomarkers and therapies.
Conclusions:
- Further understanding of extracellular matrix-microbiome interplay is crucial for advancing breast cancer treatment.
- Targeting these interactions could lead to novel therapeutic strategies and improved patient outcomes.
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