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Related Experiment Video

Updated: May 2, 2026

Analysis of Microglia and Monocyte-derived Macrophages from the Central Nervous System by Flow Cytometry

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Published on: June 22, 2017

Current Knowledge about Nonclassical Monocytes in Patients with Multiple Sclerosis, a Systematic Review.

Borros Arneth^1,2

¹Institute of Laboratory Medicine and Pathobiochemistry, Hospital of the Universities of Giessen and Marburg, UKGM, Philipps University Marburg, Baldingerst 1, 35043 Marburg, Germany.

International Journal of Molecular Sciences

|July 13, 2024

Summary

Nonclassical monocytes are key players in multiple sclerosis (MS) initiation and progression. Understanding their role can improve MS diagnostics, therapies, and disease monitoring.

Keywords:

classical-monocytes intermediate monocytes multiple sclerosis non-classical monocytes

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Last Updated: May 2, 2026

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Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis

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Published on: October 17, 2018

Area of Science:

Neuroimmunology
Immunology

Background:

Monocytes are crucial in multiple sclerosis (MS) pathogenesis.
Emerging research highlights the significance of monocytes in MS management and therapeutic development.

Approach:

This systematic review analyzed studies on nonclassical monocytes in MS and their impact on disease management.
Searches included PubMed, EMBASE, Cochrane, and Google Scholar for human and experimental autoimmune encephalomyelitis (EAE) studies from 2014-2024.

Key Points:

Nonclassical monocytes can serve as MS biomarkers.
They contribute to understanding disease pathology.
They aid in developing therapeutic interventions and monitoring disease progression.

Conclusions:

Monocytes are vital for MS pathophysiology.
Consideration of monocytes is essential for advancing MS diagnostics and therapeutics.
Further research into monocyte roles can refine MS management strategies.