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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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A High Andean Hydrocolloid Extracted by Microatomization: Preliminary Optimization in Aqueous Stability.

Yudith Choque-Quispe1,2,3,4, David Choque-Quispe2,3,4,5, Carlos A Ligarda-Samanez3,4,5,6

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A novel Altoandino Nostoc Sphaericum hydrocolloid (NSH) was optimized for aqueous suspension stability. This natural hydrocolloid shows potential as a food and pharmaceutical stabilizer, offering an eco-friendly alternative.

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Area of Science:

  • Food Science
  • Materials Science
  • Biotechnology

Background:

  • Aqueous suspensions require electrostatic interactions for stability, a challenge in food and pharmaceutical industries.
  • Synthetic stabilizers are common, but natural, eco-friendly alternatives are increasingly sought.
  • Altoandino Nostoc Sphaericum hydrocolloid (NSH) is a novel material with potential stabilizing properties.

Purpose of the Study:

  • To optimize the stability parameters of a novel NSH hydrocolloid.
  • To evaluate NSH as a potential stabilizer in aqueous suspensions.
  • To explore natural hydrocolloids as alternatives to synthetic stabilizers.

Main Methods:

  • NSH was extracted using micro atomization.
  • Suspensions were prepared using a 2^3 factorial design, varying pH, gelatinization temperature, and NSH dosage.
  • Stability was assessed via turbidity, sedimentation, zeta potential, particle size, color, and UV-Vis scanning.
  • Optimization employed empirical equations and statistical evaluation (R^2, ARE, X^2).

Main Results:

  • Optimized parameters for high stability were identified: pH 4.5, 84.55 °C gelatinization temperature, and 0.08 g/L NSH dosage.
  • Simulated stability values included high turbidity (99.00%), significant sedimentation resistance (72.34% transmittance), favorable zeta potential (-25.64 mV), and controlled particle size (300.00 nm).
  • The NSH hydrocolloid demonstrated high stability over a 20-day storage period.

Conclusions:

  • NSH shows significant potential as a natural stabilizer for aqueous suspensions.
  • Optimized NSH parameters ensure high stability, making it a viable alternative to commercial hydrocolloids.
  • Further research is needed to address NSH's color limitations for broader applications.