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Toxicology information systems: a historical perspective.

H M Kissman, P Wexler

    Journal of Chemical Information and Computer Sciences
    |August 1, 1985
    PubMed
    Summary

    Toxicology information systems have rapidly advanced from basic tools to sophisticated technologies, driven by scientific and societal needs. Future systems will integrate diverse data and adapt to new toxicological research and information technologies.

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    Area of Science:

    • Toxicology
    • Information Science
    • Computational Biology

    Background:

    • Early toxicology information systems were primarily library-based bibliographic tools.
    • The evolution of these systems mirrors the rapid expansion of toxicological science.
    • Legislation and societal concerns regarding hazardous substances spurred the development of computerized systems.

    Observation:

    • Toxicology information systems have evolved from simple bibliographic tools to complex, integrated packages.
    • Systems like TOXLINE pioneered online literature retrieval, while others (TDB, RTECS) provided literature-derived or laboratory data.
    • Advanced integrated systems are being developed to manage numerous independent toxicology databases.

    Findings:

    • Computer and telecommunication technologies have significantly shaped toxicology information systems.
    • The creation of many computerized systems was driven by societal concerns and regulations on hazardous substances.
    • Current trends include exploring integrated management systems for accessing diverse toxicology databases.

    Implications:

    • Future toxicology information systems will be influenced by microcomputers and high-density storage.
    • Advancements in biotechnology, analytical methods, and alternatives to animal testing will impact system development.
    • Integrated systems promise more efficient access to a wider range of toxicological data.

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