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Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

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Updated: May 4, 2026

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

Combined Rotating Ultra-High-Resolution Spectral Domain OCT and Scheimpflug Imaging for In Vivo Corneal Optical

Renato Ambrósio^1,2,3,4,5,6, Louise Pellegrino G Esporcatte^1,2,3, Karolyna Andrade de Carvalho^1,2

¹Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro 20520-050, Brazil.

Diagnostics (Basel, Switzerland)

|July 13, 2024

Summary

The Pentacam Cornea OCT, combining optical coherence tomography and Scheimpflug photography, offers high-resolution corneal imaging for diagnostics and optical biopsy. This advanced system provides detailed visualization of corneal layers and scattering, aiding in disease management.

Keywords:

Pentacam® Cornea OCT cornea diseases cornea ectasia spectral domain

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Last Updated: May 4, 2026

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Area of Science:

Ophthalmology
Medical Imaging
Biomedical Engineering

Background:

Corneal imaging is crucial for diagnosing and managing various eye conditions.
Existing technologies have limitations in resolution and comprehensive corneal layer visualization.

Purpose of the Study:

To introduce the Pentacam Cornea OCT, an advanced corneal imaging system.
To present the initial clinical experience and diagnostic potential of this new technology.
To evaluate its utility for optical biopsy of the cornea.

Main Methods:

A prospective study involving seven patients using the Pentacam Cornea OCT.
Utilized a novel wide-angle pericentric scan system for comprehensive corneal imaging.
Assessed the synergistic capabilities of OCT and Scheimpflug photography in image analysis.

Main Results:

The Pentacam Cornea OCT achieved significantly improved image resolution and corneal layer individualization.
Demonstrated synergism between OCT's high-definition imaging and Scheimpflug photography for scattering detection.
The noncontact examination proved safe, user-friendly, and effective for optical biopsy.

Conclusions:

Pentacam Cornea OCT represents a significant advancement in corneal imaging technology.
The system offers unprecedented detail for understanding corneal pathology and enabling optical biopsy.
Further research is needed to explore tomographic reconstructions for enhanced corneal disease diagnosis and management.