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Erythrocyte rheology.

Journal of Clinical Pathology

|September 1, 1985

Summary

This summary is machine-generated.

Erythrocyte deformability measurement has advanced using filtration and laser diffractometry. New techniques improve sensitivity and specificity for studying red blood cell rheology and drug effects.

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Area of Science:

Hematology
Biophysics
Rheology

Background:

Erythrocyte deformability was historically assessed via whole blood viscosity.
Current methods involve filtration through micro-pores or laser diffractometry for elongation measurement.

Purpose of the Study:

To detail advancements in erythrocyte deformability measurement techniques.
To highlight improved sensitivity and specificity in rheological assessments.

Main Methods:

Erythrocyte filtration through 3-5 micron pores, with improvements like reactant removal and mean cell volume consideration.
Laser diffractometry (Ektacytometer) measuring shear-induced erythrocyte elongation, corrected for mean cell volume.

Main Results:

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Enhanced filtration techniques allow detection of less deformable erythrocyte subpopulations.

Laser diffractometry, when corrected for mean cell volume, provides accurate elongation data.

Advances significantly improve the sensitivity and specificity of rheological methods.

Conclusions:

Modern rheological methods offer precise measurement of erythrocyte deformability.
These techniques are crucial for investigating the action of rheologically active drugs.