Related Experiment Video

Updated: Jun 21, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.2K

Emerging Therapeutic Strategies to Overcome Drug Resistance in Cancer Cells

Pankaj Garg1, Jyoti Malhotra2, Prakash Kulkarni2

  • 1Department of Chemistry, GLA University, Mathura 281406, India.

Cancers
|July 13, 2024
PubMed

Insights

Overcoming cancer drug resistance requires innovative strategies. This review explores targeted therapies, combination treatments, and immunotherapies to improve patient outcomes in oncology.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer drug resistance is a major obstacle in effective treatment.
  • Mechanisms include genetic mutations, altered signaling, and microenvironmental factors.
  • Novel therapeutic strategies are crucial for improving patient survival rates.

Purpose of the Study:

  • To review recent advancements in overcoming cancer drug resistance.
  • To highlight emerging therapeutic modalities and their molecular underpinnings.
  • To discuss the role of precision medicine and biomarkers in cancer therapy.

Main Methods:

  • Comprehensive literature review of current research on cancer drug resistance.
  • Analysis of molecular mechanisms driving resistance.
  • Evaluation of novel therapeutic strategies including targeted therapy, combination treatments, and immunotherapy.

Main Results:

  • Emerging strategies like targeted therapies and immunotherapies show promise in circumventing resistance.
  • Combination treatments demonstrate synergistic effects against resistant cancer cells.
  • Biomarker-driven approaches are essential for personalized treatment and monitoring.

Conclusions:

  • Integrating novel therapeutic strategies is key to overcoming cancer drug resistance.
  • Precision medicine and immunotherapy offer significant potential for improved patient outcomes.
  • Continued research into resistance mechanisms and therapeutic interventions is vital for advancing cancer care.
Keywords:
adaptive strategiesbiomarker driven approachesdrug-resistance mechanismsimmune checkpoint inhibitorsprecision medicinetargeted therapiestumor microenvironment

More Related Videos

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

10.6K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
509