Longitudinal Evaluation of Coronary Arteries and Myocardium in Breast Cancer Using Coronary Computed Tomographic Angiography
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View abstract on PubMed
Summary
This summary is machine-generated.Coronary CTA reveals changes in heart arteries and muscle after cancer treatment. Baseline artery narrowing and CT-FFR predict cardiac dysfunction in breast cancer patients receiving anthracycline therapy.
Area Of Science
- Cardio-oncology
- Radiology
- Cardiovascular Imaging
Background
- Cancer therapy-related cardiac dysfunction (CTRCD) risk is significant.
- Limited understanding of coronary computed tomography angiography (CTA) and left ventricular (LV) myocardium changes in CTRCD.
Purpose Of The Study
- Evaluate coronary artery and LV myocardium changes using coronary CTA.
- Assess patients with left breast cancer (BC) undergoing anthracycline therapy with or without radiotherapy.
Main Methods
- Prospective study of left BC patients receiving anthracycline +/- radiotherapy.
- Coronary CTA performed pre- and post-treatment, including CT-FFR, PCAT CT attenuation, and LV ECV.
- Logistic regression used to associate baseline CTA parameters with CTRCD.
Main Results
- CT-FFR decreased; PCAT CT attenuation and LV ECV increased post-treatment (P < 0.05).
- Chemoradiotherapy led to lower CT-FFR and higher PCAT CT attenuation and LV ECV compared to chemotherapy alone.
- Baseline coronary artery stenosis and CT-FFR were associated with CTRCD development.
Conclusions
- Multiparameter coronary CTA offers comprehensive assessment of coronary arteries and myocardium.
- Baseline coronary artery stenosis and CT-FFR may serve as imaging biomarkers for predicting CTRCD in this patient group.
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