Related Experiment Video
Updated: Jun 21, 2025
10:26
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
12.1K
Exploring etiologic contributions to the occurrence of external apical root resorption
John M Burnheimer1, Dylan J Baxter2, Kathleen B Deeley2
1Advanced Education Program in Orthodontics and Dentofacial Orthopedics, Seton Hill University, Greensburg, Pa.
Summary
Genetic factors like specific single nucleotide polymorphisms (SNPs) are linked to external apical root resorption (EARR) during orthodontic treatment. ACT3N and TSC2 gene variations show a significant association with EARR risk.
Area of Science:
- Genetics
- Orthodontics
- Dental Research
Background:
- External apical root resorption (EARR) is a common, undesirable outcome of orthodontic therapy.
- Previous research indicates a genetic predisposition to EARR.
- Single nucleotide polymorphisms (SNPs) are potential contributing factors.
Purpose of the Study:
- To investigate the association between EARR and various SNPs in orthodontic patients.
- To identify specific genetic markers that may predispose individuals to EARR.
Main Methods:
- 218 orthodontic patients with available radiographs were analyzed.
- EARR was quantified on a 0-4 scale using panoramic radiographs.
- DNA from saliva samples was used to analyze SNPs via PCR and TaqMan chemistry.
Main Results:
- The rs678397 SNP in ACT3N (P=0.003) and rs1051771 SNP in TSC2 (P=0.03) were significantly associated with EARR.
- No other tested polymorphisms showed a significant link to EARR.
- Class III malocclusion and longer treatment duration increased EARR risk.
Conclusions:
- Gene polymorphisms, specifically in ACT3N and TSC2, are confirmed risk factors for EARR.
- Individual patient risk factors for EARR should be clinically assessed.
- Genetic predisposition plays a role in the development of EARR.
