Ferroptosis-Modulating Natural Products for Targeting Inflammation-Related Diseases: Challenges and Opportunities in...

Area of Science:

• Biochemistry
• Cell Biology
• Pharmacology

Background:

• Ferroptosis, a distinct form of programmed cell death, is implicated in various disorders due to lipid peroxidation.
• Inflammation, a complex biological response, is closely associated with ferroptosis.
• Targeting ferroptosis pathways presents a novel therapeutic strategy for inflammatory diseases.

Purpose of the Study:

• To provide an overview of ferroptosis and its connection to inflammation.
• To explore the potential of natural products in treating ferroptosis and inflammatory conditions.

Main Methods:

• Review of cellular and animal models of inflammatory diseases.
• Analysis of signaling pathways and mechanisms linking ferroptosis and inflammation.
• Evaluation of natural products' efficacy and advantages in targeting ferroptosis.

Main Results:

• Ferroptosis markers and lipid peroxidation are elevated in inflammatory disease models.
• Natural products can target ferroptosis, including the Nrf2 pathway, to reduce inflammation.
• Natural products offer multi-component and multi-bio-targeting advantages with minimal side effects.

Conclusions:

• Ferroptosis is a key mechanism in inflammatory diseases.
• Natural products hold significant therapeutic potential for ferroptosis-driven inflammatory diseases.
• Further research on natural products could lead to innovative clinical treatments.