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The Prevalence and Factors Associated with Coronary Heart Disease in Patients with Gout
E L Markelova1, M S Eliseev2, E V Il'inykh2
1Moscow Regional Research and Clinical Institute (MONIKI), Moscow, Russia. evgenia-im@yandex.ru.
Insights
Gout patients have a high prevalence of coronary heart disease (CHD), with nearly 40% affected. Factors like obesity, gout severity, and kidney issues significantly increase CHD risk in these individuals.
Area of Science:
- Cardiology
- Rheumatology
- Epidemiology
Background:
- Gout is linked to increased cardiovascular disease (CVD) risks, including morbidity and mortality.
- Understanding the association between coronary heart disease (CHD) and gout is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of CHD in patients diagnosed with gout.
- To identify factors associated with CHD development in this patient group.
Main Methods:
- A study was conducted on 286 male patients with gout.
- Standard clinical examinations assessed traditional risk factors (TRFs) for CVD.
- Adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were calculated.
Main Results:
- Coronary heart disease (CHD) was diagnosed in 38.8% of gout patients; 29.7% had a history of myocardial infarction (MI).
- Factors significantly associated with increased CHD risk included abdominal obesity, family history of CHD, longer gout duration, early gout onset, intraosseous tophi, nephrolithiasis, renal failure, elevated serum total cholesterol, and increased serum creatinine.
- Patients with CHD were younger and had shorter gout duration compared to those without CHD.
Conclusions:
- The prevalence of CHD is substantial in patients with gout, with a significant portion having a history of MI.
- Both traditional CVD risk factors and indicators of gout severity, such as renal failure and long disease duration, contribute to CHD development in gout patients.
Abstract:
Gout is associated with increased risk of cardiovascular disease (CVD) morbidity and mortality. Therefore, an association between coronary heart disease (CHD) and gout deserves careful examination.
Aim:
. The aim of this study was to determine the prevalence of CHD and factors associated with CHD in patients (pts) with gout.
Materials And Methods:
. The study involved 286 male patients with gout, age 51.2 [42.8; 59.4] years (ys), disease duration 6.2 [3.8; 12.1] ys. All patients underwent standard clinical examination screening traditional risk factors (TRFs) of CVDs. We estimated the adjusted odds ratio (OR) and 95% confidence interval (95% CI).
Results:
. CHD was found in 111 out of the 286 pts (38.8%), MI had a history in 29.7%. Compared to individuals with CHD, participants without CHD were older (56.7[52.1; 61.1] vs 46.2[40.6; 53.4] ys), had longer duration of gout (9.3[4.7; 15.1] vs 5.6[3.3; 9.7] ys) (for all p < 0.05). Abdominal obesity (OR, 3.6; 95% CI, 1.2-10.9), family history of CHD (OR, 2.2; 95% CI, 1.3-3.7), disease duration of gout more 10 ys (OR, 2.8; 95% CI, 1.6-4.7), age of gout onset < 35 ys (OR, 5.5; 95% CI, 2.6-11.7), intraosseous tophi (OR, 3.03; 95% CI, 1.8-5.01), nephrolithiasis (OR, 1.7; 95% CI, 1.04-3.04), renal failure (OR, 5.6; 95% CI, 2.7-11.4), serum total cholesterol (TC), (OR, 1.6; 95% CI, 1.0-2.8), serum creatinine (OR, 2.5; 95% CI, 1.2-5.1), increased the risk for CHD in patients with a gout.
Conclusions:
. The prevalence of CHD was 38.8% among individuals with gout (one-third of patients had a history of MI 29.7%). Our study showed that both TRFs of CVD and the severity of gout and a history of renal failure contribute to the development of CHD in patients with gout.
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